▪ Spinal cord compression (actual or impending) and inoperable |
▪ Symptomatic brain metastasis and inoperable |
▪ Other lesions causing neurologic deficit |
▪ Pulmonary lesion causing or threatening lung obstruction |
▪ Bleeding (including hemoptysis, upper/lower gastrointestinal bleed, hematuria) |
▪ Superior vena cava obstruction (actual or impending) |
▪ Cancer-related pain, not adequately responding to analgesia |
▪ Impending pathologic fracture |